Recent Papers

Here are some recent papers that may be of interest.  My regular Crotchets & Quiddities series of  columns in Evolutionary Anthropology are listed on a separate part of my web page

Note: Most papers nowadays are downloadable from their source, such as journals.  My work can be found in the usual web-searching way on Google Scholar or PubMed.  PDFs are generally available.  However, the papers with titles in bold are dowloadable from here in pdf format or can be sent to you upon request, at

Weiss, KM Is there a 'paradigm' shift in genetics? Lessons from the study of human diseases Molecular Phylogenetics and Evolution, 5:259-265, 1996.

Weiss, K, Zhao, Z, Stock, D Dynamic interactions and dental patterning. Cr Rev Oral Biol and Med, 9:369-398, 1998

Nickerson, D, Taylor S, Weiss, K, Clark, A, Hutchinson, R, Stengard, J, Salomaa, V, Vartianinen, E, Boerwinkle, E, Sing, C DNA sequence diversity in a 9.7kb region of the human lipoprotein lipase gene. Nature Genetics, 19:233-240, 1998.

Clark, A, Weiss, K, Nickerson, D, Taylor, S, Buchanan, A, Stengard, J, Salomaa, V, Vartianinen, E, Boerwinkle, E, Sing, C Haplotype structure and population genetic inferences from nucleotide sequence variation in human lipoprotein lipase. Am J Human Genet, 63:595-612, 1998.

Weiss, KM In search of human variation. Genome Res., 8:691-697, 1998

Weiss, KM Coming to terms with human variation. Ann Rev Anthropol, 27: 273-300, 1998.

Terwilliger, J, Weiss, K. Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Op Biotechnol, 9:578-594, 1998.

Weiss, K, Fullerton, SM Phenogenetic Drift and the evolution of genotype-phenotype relationships Theor. Pop. Biol, 57: 187-195, 2000.

Weiss, K, Buchanan, A Rediscovering Darwin after a Darwinian Century, Evol Anthropol., 9: 187-200, 2000.

Weiss, K, Terwilliger, J How many diseases do you hav to study to map one gene with SNPS? Nature Genetics, 26: 151-157.

Weiss, K.M. Consulting the oracle: reverece, but circumspection Analytic book review of McKusick V, et al. Eds, Mendelian Inheritance in Man, 12th edGenetic Epidemiol 19: 468-472, 2001.

Weiss, KM *Omics: A Quick Guide. Physical Anthropol (Newsletter item), 1(4):3-4, 2001.

Buchanan, A, Risch, G, Robichaux, M, Sherry, S, Batzer, M, Weiss, K. Long DOP-PCR of rare archival anthropological samples. Human Biology 72: 911-926, 2001.

Fullerton SM, Clark AG, Weiss KM, Nickerson DA, Taylor SL, Stengard JH, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing CF. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism Am J Hum Genet. 67:881-900, 2001.

Zhao, Z, Stock, D, Buchanan, A, Weiss, K. Expression of Dlx genes during murine dental development,Dev, Genes, Evol., 210: 270-275, 2001.

Weiss, K. Revisiting phenotypes in an age of genotypes. Am J Phys Anthropol, 111: 295-299, 2001.

Weiss, K, Clark, A Linkage disequilibrium and the mapping of complex human traits. Trends in Genetics, 18:19-24, 2002.

Sumiyama, K, Irvine, S, Stock, D, Weiss, K, Kawasaki, K, Shimizu, N, Shashikant, C, Miller, W, Ruddle, F. Genomic structure and functional control of the Dlx3-7 bigene cluster Proc Nat Acad Sci 99: 780-785, 2002.

Hlusko, L, Mahaney, M, Rogers, J, Weiss, K. A Comparison of Two Techniques to Describe Molar Crown Size: Estimated Crown Area versus Actual Crown Area. Am J Phys Anth, 117: 172-189, 2002.

Weiss, K, Schull, W Perspectives fulfilled: the work and thought of JV Neel (1915-2000) Persp. Biol.Med, 45:46-64, 2002.

Kawasaki, K, Weiss, KM Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster Proc Nat Acad Sci 100:4060-4065, 2003.

Weiss, K., Buchanan, A. Evolution by phenotype: a biomedical perspective Pers. Biol. Med. 46: 159-182, 2003.

Weiss, K. Richard H Ward: W ild Ride of the Valkyries (obituary). Am. J. Hum. Genet. 72:1079-1083, 2003.

Stengard, J. et al. Contributions of 18 additional DNA sequence variations in the gene encoding for apolipoprotein E to explaining variation in quantitative measures of lipid metabolism Am J Hum Genet, 71: 501-517, 2003.

Fullerton, SM et al. Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in African-American sample Hum. Genet. 111: 75-87, 2004.

Terwilliger, JG, Weiss, KM  Confounding, ascertainment bias, and the quest for a genetic "Fountain of Youth". Annals of Medicine, 35:532-544, 2003.

Kittles, R, Weiss, KM Race, ancestry, and genes: implications for defining disease risk. Annual Rev Human Genomics and Human Genetics, 4: 33-67, 2003.

Weiss, K. Thomas Henry Huxley (1825-1895) puts us in our placeM Exper Zool/Mol Dev Evol, 302B: 196-206, 2004.

Weiss, K. The unkindest cupThe Lancet, 363: 1489-1490, 2004.

Kawasaki, K, Suzuki, T, Weiss, K. Genetic basis for the evolution of vertebrate mineralized tissue, Proc. Natl. Acad. Sci., 101:11356-61, 2004.

Fullerton, SM et al. The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Hum. Genet. 115: 36-56, 2004.

Sholtis, S, Weiss, K. Phenogenetics: Genotype-phenotype interactions and variation. In B Hallgrimsson and BK Hall, eds., Variation, NY: Academic Press.

Weiss, K. The phenogenetic logic of life. Nat. Rvws Genet. 6: 36-45, 2005.

Weiss, K. Cryptic causation of human disease: reading between the (germ) lines. Trends in Genetics, 21(2): 82-88.

Weiss, K. Polymorphisms: origin and maintenanceEncyclopedia of the Life Sciences

Weiss, K., Buchanan, A. Concept of complex trait geneticsCambridge Encyclopedia of Genetics, 
Genomics, Proteomics And Bioinformatics
, Ch 58.

Weiss, K. 'Genetic': one word, several meanings. Invited chapter for Scriver, C. et al., eds,
The Metabolic and Molecular Basis of Inherited Disease, Chapter 2.1.

Weiss, K. Allele spectrum in human genetic disease, Encyclopedia of the Life Sciences.

Buchanan, A, Weiss, K , Fullerton, SM Dissecting complex disease: the quest for the philosopher’s 
stone? (a forum article with commentary and our reply),
International J. Epidemiol. 35: 562-596, 2006.

Kawasaki, K, Weiss, K Phenogenetic drift in vertebrate tooth evolution: the changing genetic basis of vertebrate teeth, PNAS, 102: 18063-68, 2005.

Kawasaki , K, Weiss, K. Evolutionary genetics of vertebrate tissue mineralization: the origin 
and evolution of the secretory calcium-binding phosphoprotein family
. Mol. Dev. Evol./J Exper Zool. 306:295-316, 2006.

Kwasaki, K, Weiss, K , Genetic Basis for the Evolution of Vertebrate Mineralized Tissue. In, Baeuerlein, E, Ed.,Handbook Of Biomineralization, Vol. 1: The Biology of Biominerals Structure Formation, Chapter 21, Berlin, Wilyey-VCH, 2006.

Weiss, K., Smith, FH Out of the veil of death rode the one million! Neandertals and their genes.
BioEssays, invited commentary, 29(2):105-110, 2007. 

Kawasaki, K,Buchanan, A., Weiss, K Gene Duplication and the Evolution of Vertebrate Skeletal 
, Cells, Tissues, and Organs, 186, No. 1, 7 – 24, 2007

Weiss, K. On babies and bathwater (Commentary). Amer. Ethnol., 34:240-242.

Mao, X, Bigham, A, Mei, R., Gutierrez, G, Weiss, K, Brutsaert, T, Leon-Velarde, F, Moore, L.,   McKeigue, P., Shriver, M., Parra, E. A genome-wide admixture mapping panel for Hispanic/Latino  populations. Am. J. Hum. Genet., 80:1171-1178.

Weiss, K.  Overview thoughts on genetics:  Walking the line between denial and dreamland, or genes are  involved in everything but not everything is ‘genetic’. Chapter 12 in Weinstein, M, Vaupel, J, Wachter,  K, Eds.  Biosocial Surveys.  Washington, National Academies Press, pp 231-247.

Kawasaki, K, Weiss, K  SCPP genes and the dental tissue continuum.  J Dent Res., 87(6):520-531.

Weiss, K. Tilting at Quixotic Trait Loci (QTL): An evolutionary perspective on genetica causation. Genetics 179: 1741-1756, 2008.

Weiss, K., Buchanan, A  The cooperative genome: organisms as social contracts. Int J. Dev. Biol., 53: 753-763.

Lambert, B, Terwilliger, J, Weiss, K  ForSim: A tool for exploring the genetic architecture of complex traits with controlled truth.  Bioinformatics, 24: 1821-1822, 2008.

Buchanan, A, Sholtis, S, Richtsmeier, J, Weiss, K.  What are genes for?  How are traits Made? What is the Quiestion?
BioEssays, 31: 198-208, 2009.

Weiss, K., Long, J. Non-Darwinian estimation: My ancestors, my genes' ancestors. Genome Research, 19: 703-710.

Weiss, K.  Having a Jolly good time—together!  Or Evolution by Cooperative Interaction.  Curr.  Anthropol., 50: 235-245, 2009.

Kawasaki, K, Buchanan, A, Weiss, K. Biomineralization in humans: making the hard choices in life. Ann. Rev. Genet., 43: 119-142, 2010.

Weiss, K, Buchanan, A. Evolution: what it means and how we know. In Larsen, CG, Ed., Companion to BIological Anthropology, 41-55, 2010

Weiss, K When the time seems ripe: eugenics and ther persistence of subtle typological thinking. Annals of Human Genetics, 75:334-343, 2011.

Weiss, K, Buchanan, A Is life law-like? Genetics, 188: 761-771, 2011.

Weiss, K. Genetics without ideology. GeneWatch, 24: 43-45, 2011.

Wagner, JK, Weiss, KM Attitudes on DNA ancestry tests.  Human Genetics, pub online June 2011.

Weiss, K, Buchanan, A, Lambert, BW. The Red King and his Queen: cooperation at all levels of life.  Yearbook of Physical Anthropology, 54:3-18.

Weiss, K.  Marry a quean and be merry: many paths to the same mood. Crotchets & Quiddities, Evol. Anth., 20: 164-168.

Weiss, K.  The positive power of negative results.  Proc. Am College Vet Pathol.


Tero Hiekkalinna, Harald HH Göring, Brian Lambert, Kenneth M. Weiss, Petri Norrgrann, Alejandro A. Schäffer, and Joseph D Terwilliger.   On the statistical properties of family-based association tests in datasets containing both pedigrees and unrelated case-control samples, 2011 EurJHumGen 20: 217-223.

Weiss, K.  Analogy recapitulates homology?  Evol. Biol., 39:25-26.

Weiss, K. The Intelligent Egg.  Evol.: Educ & Outreach, 5: 194-202, 2012.

Weiss, K.  What makes us human?  Invited commentary, Evol. Anth., 21:192, 2012.


Weiss, K., Buchanan, A.  Things genes can’t do: simplistic ideas of how genes ‘cause’ traits are no longer viable: life is an orderly collection of uncertainties.  Aeon, April 9, 2013.

Weiss, K, Buchanan A  Gregor Mendel.  Oxford Bibliographies, Anthropol (online)

Weiss,K, Buchanan A. Is genetics a 'religion'?  GeneWatch 26(4) online

Moore, CB et al., Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 Genomes Project data.  PLoS Genetics, December.


Weiss, K, Lambert, B.  What type of person are you? Persistent typological thinking about human variation.  Cold Spr Harbor Persp in Biol 6:1-14 (and as a chapter in Chakravarti, A, Ed.,  Human Variation: A Genetic Perspective on DIversity, Race and Medicine.  Cold Spr Harbor Press)

Kawasaki, K, Weiss, K.  Teeth and Bones: An Overview.  Chapter 59 in Zeeb, M and Lammert E, Eds., Vienna: Springer, pp 81-85. inciples of Metabolism in Health and Disease.

Weiss, K.  Genomic and evolutionary challenges for biodemography.  In Weinstein, M., Lane, M, Eds, Sociality, Hierarchy, Heath: Comparative Biodemography.  Washington: National Academy Press, pp. 95-120.


Weiss, K Genetic Variation and Human Disease: Princples and Evolutionary Approaches. Cambridge Univ. Press, 1992.

Weiss, KM, Buchanan, AV Genetics and the Logic of Evolution. NY, J. Wiley, 2004.

Weiss, K, Buchanan, A.  The Mermaid’s Tale: Four Billioin Years of Cooperation in the Making of Living Things .  Harvard Univ Press, in press, due winter 2009.